Nūhou

Ua waiwai ʻia nā mea kanu lāʻau kuʻuna i nā makahiki no ka hāʻawi ʻana i ka ʻike i nā ʻano maʻi.Eia naʻe, ʻo ka hoʻokaʻawale ʻana i nā molekala maikaʻi mai ka milieu o nā pūhui i hoʻokumu i ka hapa nui o nā ʻano mea kanu he hana paʻakikī.I kēia manawa, ua hoʻomohala nā mea noiʻi ma ke Kulanui o Toyama, Iapana i kahi ala e hoʻokaʻawale a ʻike i nā pūhui ikaika i nā lāʻau lapaʻau.

Nā ʻikepili hou—i paʻi ʻia ma Frontiers in Pharmacology i kahi ʻatikala i kapa ʻia, "ʻO kahi hoʻolālā hoʻolālā no ka ʻike ʻana i kahi lāʻau lapaʻau lapaʻau no ka maʻi Alzheimer a me kāna molekule pahuhopu.", e hōʻike ana i kahi ʻenehana hou e ʻike ai i nā pūhui ikaika mai Drynaria rhizome, kahi lāʻau lapaʻau kuʻuna, e hoʻomaikaʻi i ka hoʻomanaʻo a hōʻemi i nā ʻano maʻi i loko o kahi ʻano ʻiole o ka maʻi Alzheimer.

ʻO ka maʻamau, e nānā pinepine nā ʻepekema i nā lāʻau lapaʻau maʻemaʻe i nā hoʻokolohua lab e ʻike ai inā hōʻike kekahi pūhui i ka hopena i nā cell i ulu in vitro.Inā hōʻike ka pūhui i ka hopena maikaʻi i loko o nā cell a i ʻole nā ​​paipu hoʻāʻo, hiki ke hoʻohana ʻia ma ke ʻano he lāʻau lapaʻau, a e hoʻāʻo nā ʻepekema i nā holoholona.Eia nō naʻe, paʻakikī kēia kaʻina hana a ʻaʻole helu i nā loli e hiki ke loaʻa i nā lāʻau i ka wā e komo ai i loko o ke kino-hiki i nā enzyme i loko o ke koko a me ke ake ke hoʻololi i nā lāʻau i nā ʻano like ʻole i kapa ʻia he metabolites.Eia hou, paʻakikī kekahi mau wahi o ke kino, e like me ka lolo, no nā lāʻau lapaʻau he nui, a ʻo kekahi mau lāʻau lapaʻau a i ʻole nā ​​metabolites e komo i kēia mau kiko.

"ʻO nā pūhui moho i ʻike ʻia i loko o nā pale lāʻau lapaʻau kuʻuna benchtop o nā lāʻau lāʻau, ʻaʻole ia he mau pūhui ikaika maoli no ka mea ke nānā ʻole nei kēia mau ho'āʻo ʻana i ka biometabolism a me ka hāʻawi ʻana i nā kiko," i wehewehe ʻia ai ka mea noiʻi noiʻi kiʻekiʻe ʻo Chihiro Tohda, Ph.D., ke kaukaʻi o neuropharmacology ma ke Kulanui o Toyama. ."No laila, ua manaʻo mākou e hoʻomohala i nā ala ʻoi aku ka maikaʻi e ʻike ai i nā pūhui ikaika maoli e noʻonoʻo nei i kēia mau mea."

I loko o ke aʻo ʻana, ua hoʻohana ka hui ʻo Toyama i nā ʻiole me ka mutation genetic i kumu hoʻohālike no ka maʻi o Alzheimer.Hāʻawi kēia hoʻololi i nā ʻiole i kekahi mau hiʻohiʻona o ka maʻi o Alzheimer, me ka hoʻemi ʻana i ka hoʻomanaʻo a me ke kūkulu ʻana i nā protein kikoʻī i loko o ka lolo, i kapa ʻia ʻo amyloid a me tau proteins.

"Ke hōʻike nei mākou i kahi hoʻolālā ʻōnaehana no ka loiloi ʻana i nā moho bioactive i nā lāʻau kūlohelohe i hoʻohana ʻia no ka maʻi o Alzheimer (AD)," i kākau ai nā mea kākau."Ua ʻike mākou hiki iā Drynaria rhizome ke hoʻonui i ka hana hoʻomanaʻo a hoʻomaikaʻi i nā pathologies AD i nā ʻiole 5XFAD.Ua alakaʻi ʻia ka loiloi biochemical i ka ʻike ʻana i nā metabolites bioeffective i hoʻoili ʻia i ka lolo, ʻo ia hoʻi, naringenin a me kāna glucuronides.No ka ʻimi ʻana i ke ʻano o ka hana, ua hui pū mākou i ka lāʻau affinity responsive target stability me ka immunoprecipitation-liquid chromatography/mass spectrometry analysis, e ʻike ana i ka protein collapsin pane mediator protein 2 (CRMP2) ma ke ʻano he naringenin.

Ua ʻike ka poʻe ʻepekema ua hoʻemi ka mea kanu i nā hemahema o ka hoʻomanaʻo a me nā pae o nā protein amyloid a me tau i loko o ka lolo ʻiole.Eia kekahi, ua nānā ka hui i ka ʻiʻo lolo o ka ʻiole i ʻelima mau hola ma hope o ka mālama ʻana i nā ʻiole me ka extract.Ua ʻike lākou ua hoʻokomo ʻia ʻekolu pūhui mai ka mea kanu i loko o ka lolo—naringenin a me ʻelua mau metabolites naringenin.

I ka mālama ʻana o nā mea noiʻi i nā ʻiole me ka naringenin maʻemaʻe, ʻike lākou i ka hoʻomaikaʻi like ʻana i nā hemahema o ka hoʻomanaʻo a me ka hōʻemi ʻana i nā protein amyloid a me tau, e hōʻike ana ʻo ka naringenin a me kāna mau metabolites nā mea hana i loko o ka mea kanu.Ua loaʻa iā lākou kahi pūmua i kapa ʻia ʻo CRMP2 i hoʻopaʻa ʻia e naringenin i loko o nā neurons, kahi e ulu ai lākou, e manaʻo ana ʻo ia ke ʻano e hiki ai i ka naringenin ke hoʻomaikaʻi i nā hōʻailona maʻi o Alzheimer.

Manaʻo ka poʻe noiʻi e hiki ke hoʻohana ʻia ka ʻenehana hou e ʻike i nā lāʻau lapaʻau ʻē aʻe."Ke noi nei mākou i kēia ʻano e ʻike ai i nā lāʻau lapaʻau hou no nā maʻi ʻē aʻe e like me ka ʻeha spinal cord, depression, a me sarcopenia," i ʻōlelo ai ʻo Dr. Tohda.